Mannich reaction derivatives of novobiocin with modulated physiochemical properties and their antibacterial activities
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چکیده
منابع مشابه
SYNTHESIS OF PARACETAMOL DERIVATIVES AS MANNICH BASES AND THEIR ANTIBACTERIAL ACTIVITY
Aim: A variety of Paracetamol derivatives as mannich bases were prepared through mannich reaction by reacting Paracetamol as compound containing active hydrogen, substituted benzaldehyde, morpholine as secondary amine compound and small amount of conc. HCl as catalyst. A simplistic one-pot method under mild conditions has been developed for the synthesis of all the compounds and they were chara...
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چکیده ندارد.
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Citral, a bioactive compound in Palmrose oil, although known to have antibacterial effect, has not been used in current drug research. Optimization of the lead structure could enhance the utility of this compound. Hence citral was modified using natural amino acids to produce the Schiff’s base, a potential pharmacophore and the corresponding amines. In this study, we report the synthesis of 9 S...
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Background and purpose: Microbial resistance against antibiotics is increasingly growing, therefore, it is necessary to develop new remedies. Silver nanoparticles have significant antibacterial properties and synthesis of silver nanoparticles mediated by plant extracts could be considered as an alternative in treatment in various infections. Materials and methods: In this study, silver nano...
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ژورنال
عنوان ژورنال: Bioorganic & Medicinal Chemistry Letters
سال: 2011
ISSN: 0960-894X
DOI: 10.1016/j.bmcl.2011.08.035